The Triad of Brain Plasticity Induction: A Method to Treat Mental Disorders More Effectively

Resumen

How can we improve treatment response in mental disorders? First, we generate an educated hypothesis for the aetiology of these disorders; The “Neuroanalytic” hypothesis, that defines “plasticity” as the basic mechanism for the disorders and thus also for the treatment. We define 3 types of plasticity dynamics in the ‘space time’ of brain dimensions, and correlate them with the phenomenology of the disorders. Disturbances to fast millisecond-range Plasticity disrupt conscious integration with symptoms of psychosis and schizophrenia. Disturbances to slower Adaptive Plasticity that optimizes internal representations and reduces predictive error will result in mood disorders. A de-optimized brain with free energy increases results in the emergent property of depression and vice versa. Optimization dynamics is mood elevating i.e., may produce possible manic symptoms. Finally, altered internal representations of psychosocial occurrences due to “immature” biased Default-Mode resting brain network organization results in personality-related distortions. This leads to ineffective, biased social interactions and an emergent property of personality disorders. The neuroanalytic approach can be applied to plasticity dynamics and can be expressed in terms of ‘Fast,’ ‘Slow’ and ‘Lifelong’ plasticity ranges. Fast for the psychosis and schizophrenia spectrum, slow for mood disorders and lifelong for personality disorders. According to these Neuroanalytic insights, three therapeutic interventions are proposed: ‘Medication Plasticity,’ ‘Direct (electrophysiological) Plasticity,’ and ‘Experience-Dependent Plasticity,’. Their combination is presented as improved retreatments for mental disorders.

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Cómo citar (APA 7)

Peled, A. (2023). The Triad of Brain Plasticity Induction: A Method to Treat Mental Disorders More Effectively. https://doi.org/10.31234/osf.io/s2kba